Near-infrared optical imaging of proteases in cancer.

Improving 3-D Imaging Breast Cancer Diagnosis Systems Using a New Method for Placement of Near-Infrared Sources and Detectors

The objective of this research was to improve 3-D imaging system by near-infrared light emission in breast tissue to achieve a more accurate diagnosis of tumor. The results of repeated experiments in this research have shown that with this imaging system, a more accurate diagnosis of abnormal area depends on the location of the sources and detectors. Therefore, an optimal location model has bee...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom

Optical Imaging of the Motor Cortex in the Brain in Order to Determine the Direction of the Hand Movements Using Functional Near-Infrared Spectroscopy (fNIRS)

Introduction: In recent years, optical imaging has attracted a lot of attention from scholars as a non- aggressive, efficient method for evaluating the activities of the motor cortex in the brain. Functional near-infrared spectroscopy (fNIRS (is a tool showing the hemodynamic changes in a cortical area of the brain according to optical principles. The present study has been de...

Optical Imaging of Cancer-Related Proteases Using Near-Infrared Fluorescence Matrix Metalloproteinase-Sensitive and Cathepsin B-Sensitive Probes

Cathepsin B and matrix metalloproteinase (MMP) play key roles in tumor progression by controlled degradation of extracellular matrix. Consequently, these proteases have been attracted in cancer research, and many imaging probes utilizing these proteases have been developed. Our groups developed cathepsin B and MMP imaging nanoprobes based on polymer nanoparticle platform. Both cathepsin B and M...

Quantitative Comparison of Analytical solution and Finite Element Method for investigation of Near-Infrared Light Propagation in Brain Tissue Model

Introduction: Functional Near-Infrared Spectroscopy (fNIRS) is an imaging method in which light source and detector are installed on the head; consequently, re-emission of light from human skin contains information about cerebral hemodynamic alteration. The spatial probability distribution profile of photons penetrating tissue at a source spot, scattering into the tissue, and being released at ...